[pubmed] Update in immunosuppressive therapy of myasthenia gravis

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Autoimmun Rev. 2020 Nov 13:102712. doi: 10.1016/j.autrev.2020.102712. Online ahead of print.

ABSTRACT

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction. Immunosuppressive treatments are part of the therapeutic armamentarium in MG. Long-term systemic steroid administration carry considerable risks and adverse events. Consequently, steroid-free immunosuppressive therapy is necessary to reduce the dose or discontinue steroids. First immunosuppressive drug trials in MG, were performed in the mid-60s, using standard and nonspecific immunosuppression. Since then, only few randomized controlled clinical trials were developed in MG, showing inconclusive results; and drug efficacy was assessed in terms of its steroid-sparing capacity and the ability to reduce myasthenic signs and symptoms. Treatment strategy in MG is quite challenging, mainly due to the disease heterogeneity in terms of clinical presentation, immunopathogenesis and drug response. To solve this dilemma, emerging treatment are based on biological drugs and use new targets of the immune pathway.

PMID:33197578 | DOI:10.1016/j.autrev.2020.102712


Source: https://pubmed.ncbi.nlm.nih.gov/3319757 ... 7&v=2.13.0