[pubmed] The Duke Myasthenia Gravis Clinic Registry: I. Description and Demographics

Intégration des publications parues sur PUBMED
Avatar du membre

Auteur du sujet
Ami(e) de Diamant
Ami(e) de Diamant
Messages : 519
Enregistré le : 31 mai 2020 09:57
    Macintosh Safari
Zodiaque :
Âge : 21

[pubmed] The Duke Myasthenia Gravis Clinic Registry: I. Description and Demographics

Message par RSS-Bot »

Muscle Nerve. 2020 Nov 17. doi: 10.1002/mus.27120. Online ahead of print.


INTRODUCTION: The Duke Myasthenia Gravis (MG) Clinic Registry is a disease-specific database containing physician-derived data from patients seen in the Duke MG Clinic since 1980.

METHODS: Data from 1,060 MG patients initially seen between 1980 and 2008 were reviewed.

RESULTS: Fifty-four percent were male. Symptoms began after age 50 in 66% of males and 42% of females. Peak onset age in males was in their 60's; females had no predominant onset age. Onset age for both sexes increased from 1980 to 2008. Thymoma was present in 8.5%. Weakness was limited to ocular muscles for at least 2 years in 22% and became generalized later in 8.3% of these. Acetylcholine receptor antibodies were present in 78% overall, 82% with generalized MG and 52% with ocular MG (OMG). The distribution of MG disease class was similar in males and females, except that a greater proportion of women experienced myasthenic crisis and men were more likely to have OMG.

DISCUSSION: Data in the Registry permit comprehensive and longitudinal analysis of a validated MG population. Analysis of Registry data shows that the frequency of AChR antibody negative MG, ocular MG, and thymoma are similar to other reports, but the onset age and proportion of males have progressively increased compared to studies published more than 20 years ago. These observations demonstrate the value of collecting comprehensive clinical information and comparing historic and contemporary populations. Other potential uses of Registry data include comparison of outcome measures in different disease subgroups and the response to specific treatments.

PMID:33205437 | DOI:10.1002/mus.27120

Source: https://pubmed.ncbi.nlm.nih.gov/3320543 ... 8&v=2.13.0
Si vous appréciez notre travail, merci de nous soutenir un petit don en cliquant ICI

Pour obtenir la traduction en français,
cliquez sur le bouton situé dans la barre des menus en haut de cette page 


Pour les donateurs, si cet article vous intéresse, nous pouvons faire l’acquisition d'un tiré-à-part.
Merci d'en faire la demande sur association.amis-modo@myasthenie.com

Bonne lecture...

Retourner vers « Echos de la recherche »