[pubmed] Myocarditis and myasthenia gravis by combined nivolumab and ipilimumab immunotherapy for renal cell carcinoma:

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Urol Case Rep. 2020 Nov 28;34:101508. doi: 10.1016/j.eucr.2020.101508. eCollection 2021 Jan.

ABSTRACT

Ipilimumab plus nivolumab (Ipi/Nivo) has revolutionized advanced renal cell carcinoma (RCC) treatment. However, it encompassed fatal immune-related adverse events (irAEs). Myocarditis with concomitant myasthenia gravis (MG) has a mortality rate of 50%, and a high dose of methylprednisolone (mPSL) should be administered with careful attention to MG exacerbation. We present the case of a 59-year-old man with progressing lung metastasis of RCC. After one cycle of Ipi/Nivo, he experienced myocarditis and MG, managed by mPSL pulse therapy, plasma exchange, and high-dose intravenous immunoglobulin. We share the therapeutic course, aiming to contribute to the limited literature on rare but aggressive irAEs.

PMID:33318935 | PMC:PMC7726655 | DOI:10.1016/j.eucr.2020.101508


Source: https://pubmed.ncbi.nlm.nih.gov/3331893 ... 3&v=2.13.0