[pubmed] Myasthenia Gravis Revealing Hodgkin's Lymphoma

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Eur J Case Rep Intern Med. 2021 Mar 12;8(3):002375. doi: 10.12890/2021_002375. eCollection 2021.

ABSTRACT

INTRODUCTION: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction.

PATIENT AND METHODS: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma.

RESULTS: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ≤0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin's lymphoma.

CONCLUSION: The association of lymphomas with myasthenia gravis has been rarely reported.

LEARNING POINTS: Myasthenia gravis is an autoimmune disease of the neuromuscular junction and can be associated with malignant haemopathy.The coexistence of myasthenia and Hodgkin's lymphoma is very rare.This association is a therapeutic challenge.

PMID:33987113 | PMC:PMC8112101 | DOI:10.12890/2021_002375


Source: https://pubmed.ncbi.nlm.nih.gov/3398711 ... 3&v=2.14.4