[Pubmed] Autoantibody detection by a live cell-based assay in conventionally antibody-tested triple seronegative Myasthe

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Neuromuscul Disord. 2023 Jan 6:S0960-8966(23)00002-0. doi: 10.1016/j.nmd.2023.01.002. Online ahead of print.

ABSTRACT

Autoantibody testing is the mainstay in confirming the diagnosis of autoimmune myasthenia gravis (MG). However, in approximately 15% of patients, antibody testing in clinical routine remains negative (seronegative MG). This study aimed at assessing the prevalence of "clustered" AChR- and MuSK- and LRP4- autoantibodies using a live cell-based assay in a large German cohort of seronegative myasthenia gravis (SNMG) patients. A total of 67 SNMG patients were included. Clustered AChR-ab were identified in 4.5% (n = 3) of patients. Two out of the three patients showed binding to the adult AchR as well as the fetal AchR. None of the patients was positive for MuSK- or LRP4-autoantibodies. There were no differences in clinical characteristics between the patients with and without clustered AChR-ab detection. Comparison of clinical data of our cohort with clinical data from the nationwide Myasthenia gravis registry showed broad similarities between seronegative MG patients of both cohorts.

PMID:36746691 | DOI:10.1016/j.nmd.2023.01.002


Source: https://pubmed.ncbi.nlm.nih.gov/3674669 ... t6+86293ac