Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29040921
[ligne][/ligne]
Traduction disponible directement en cliquant en bas à droite de ce message sur notre forum
[ligne][/ligne]
Message d' un membre de l'équipe technique |
Il s'agit du test du glaçon |
Effect of local cooling on excitation-contraction coupling in myasthenic muscle: Another mechanism of ice-pack test in myasthenia gravis.
Yamamoto D1, Imai T2, Tsuda E1, Hozuki T3, Yamauchi R4, Hisahara S1, Kawamata J1, Shimohama S1.
Clin Neurophysiol. 2017 Sep 22;128(11):2309-2317. doi: 10.1016/j.clinph.2017.08.030. [Epub ahead of print]
Abstract
- OBJECTIVE:
The ice-pack test is a convenient diagnostic testing procedure for myasthenia gravis (MG). We investigated the underlying mechanism of the ice-pack test performed on bilateral masseters.
- METHODS:
We performed trigeminal repetitive nerve stimulation (RNS), excitation-contraction (E-C) coupling assessment (Imai's method) and bite force measurement before and after cooling of the masseters in MG patients and normal controls. After placing the ice-pack on the masseters for 3min,- serial recordings of the three tests were performed at various time intervals during 10min after cooling.
RESULTS:
The bite force increased significantly after cooling in ice-pack-positive MG patients. The acceleration and acceleration ratio (acceleration at a given time to baseline acceleration) of jaw movement increased significantly after cooling of the masseters in ice-pack-positive MG patients compared to ice-pack-negative patients and normal controls. The prolonged effect of cooling continued until the end of recording even though decremental response to RNS had returned to baseline value.
- CONCLUSIONS:
Cooling of myasthenic muscle may induce two effects. One is relatively short effect on electrical synaptic transmission at the endplate, and another is prolonged effect on E-C coupling in the muscle.
- SIGNIFICANCE:
The ice-pack test induces a prolonged effect of ameliorating impaired E-C coupling in MG.
Lien Google Traduction https://translate.google.fr/translate?h ... 2F29040921
Message d' un membre de l'équipe technique |
Nous utilisons un service automatique de traduction fourni par YANDEX. Soyez vigilant sur le risque de contre-sens inhérent à ce genre d'outils. |