Expression abérante de la CAVEOLIN 3 dans les cellules musculaires squelettiques de MG
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Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis
Kazuo Iwasaa, , , Yutaka Furukawab, , Hiroaki Yoshikawac, , Masahito Yamadaa,
Journal of Neuroimmunology, Volume 301, 15 December 2016, Pages 30–34
Abstract
Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development.
The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles.
Caveolin-3 was abnormally expressed in the MG muscle membrane, with partial loss of expression and overexpression in 5/15 and 10/15 patients, respectively.
Caveolin-3 mRNA and protein levels were higher in MG than in control muscles, suggesting that partial deficiency of caveolin-3 is occasionally detected in MG muscle and that caveolin-3 overexpression may be required after MG muscle damage.