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Le Jitter prédit-il ou se corrèle-t-il avec l'évolution clinique de la Myasthénie ?

Posté : 16 févr. 2017 09:50
par Pboulanger
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Lu sur http://onlinelibrary.wiley.com/wol1/doi ... 0/abstract
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Does change in neuromuscular jitter predict or correlate with clinical change in MG?
Donald B. Sanders MD* andJanice M. Massey MD
Version of Record online: 15 FEB 2017 DOI: 10.1002/mus.25440


ABSTRACT


  • Introduction
    The objective of this study was to determine if single-fiber electromyography (SFEMG) jitter accurately reflects change in severity in myasthenia gravis (MG).


  • Methods
    We reviewed jitter and outcome data from all MG patients in our clinic who had at least 2 jitter measurements in the extensor digitorum or frontalis muscle.


  • Results
    Change in all parameters of jitter measured with SFEMG electrodes predicted clinical change with acceptable accuracy. Absolute and percentage change in mean value of consecutive interval differences were equally accurate in predicting clinical change and were more accurate than change in the proportion of fiber pairs with blocking or normal jitter.


  • Conclusions
    Jitter is a sensitive measure of severity in MG and has a potential role as a biomarker in clinical trials and the clinic. Absolute or percentage change in mean jitter is the best jitter parameter to follow. The accuracy of change in jitter measured with other electrodes has yet to be determined.