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Etude pilote sur la sécurité des exercices phypiques pour un myasthénique et sur l'amélioration des paramètres neuro...

Posté : 04 avr. 2017 21:28
par Pboulanger

Lu sur ... 3/abstract

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Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study
Elisabet Westerberg MD1,2, Carl Johan Molin MD1, Ida Lindblad MSc1, Margareta Emtner PhD3,4 andAnna Rostedt Punga MD, PhD1,*

Version of Record online: 2 APR 2017 DOI: 10.1002/mus.25493

  • Introduction:
    Due to the shortage of exercise-related research in Myasthenia Gravis (MG), there are no consensus guidelines on physical exercise for MG patients.
  • Methods:
    In this prospective pilot study, 10 MG patients with mild disease performed supervised aerobic and resistance training twice weekly for 12 weeks. The Myasthenia Gravis Composite (MGC) score, compound motor action potential (CMAP), repetitive nerve stimulation, muscle force, physical performance-based measures, serum levels of interleukin-6, muscle enzymes, and immuno-microRNAs miR-150-5p and miR-21-5p were assessed before and after the training period.
  • Results:
    Physical exercise was well tolerated, and the MGC score was unchanged. Muscle resistance weights and CMAP amplitudes increased for biceps brachii and rectus femoris muscles, and physical performance-based measures improved. Muscle enzymes remained normal, whereas disease-specific microRNAs miR-150-5p and miR-21-5p were reduced after the training period.
  • Conclusions:
    We propose that general recommendations regarding physical exercise can be applied safely to well-regulated MG patients.