Effets bénéfiques du TOCILIZUMAB dans les myasthénies réfractaires au RITUXIMAB

Verrouillé
Avatar du membre

Auteur du sujet
Pboulanger Prés.
Administrateur
Administrateur
Messages : 10762
Enregistré le : 02 févr. 2010 18:41
14
Localisation  : La Chapelle en Serval F-60520
Genre :
Zodiaque :
Âge : 67
    Windows 10 Firefox

Effets bénéfiques du TOCILIZUMAB dans les myasthénies réfractaires au RITUXIMAB

Message par Pboulanger Prés. »

:hi:

Lu sur https://www.ncbi.nlm.nih.gov/pubmed/28433474

Traduction disponible directement en cliquant en bas à droite de ce message sur notre forum

Image

Beneficial effect of tocilizumab in myasthenia gravis refractory to rituximab.
Jonsson DI1, Pirskanen R2, Piehl F3.
PMID: 28433474 DOI: 10.1016/j.nmd.2017.03.007


Abstract

Muscle fatigue associated with myasthenia gravis is caused by autoantibodies interfering with neuromuscular transmission.
Immunomodulating treatment is widely used in moderate to severe myasthenia, although the use of newer biological drugs except rituximab is rare.

We describe the effect of tocilizumab, a blocker of interleukin-6 signalling, in two female myasthenia patients with high titres of serum acetylcholine receptor antibodies and insufficient response to rituximab.

The first patient had been treated with high dose immunoglobulins regularly for several years and the second patient had been treated both with different oral immune suppressants and immunoglobulins before testing a low dose of rituximab without significant clinical effect.

Subsequent treatment with tocilizumab resulted in clinical improvement within a few months. The first patient was switched back to rituximab, which resulted in worsening until tocilizumab was restarted.

Tocilizumab can be a therapeutic option in cases not responding to rituximab.

Amicalement,
Image
Verrouillé

Retourner vers « 2017 »