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Une réponse rapide à la Prednisone prédit un parcours bénin dans MuSK-MG.

Posté : 13 août 2017 10:53
par Pboulanger
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:arrow: Lu sur : https://www.ncbi.nlm.nih.gov/pubmed/?te ... d=28768265
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Prompt Response to Prednisone Predicts Benign Course in MuSK-MG.

Gungor-Tuncer O1, Yilmaz V2, Toker A3, Saruhan-Direskeneli G2, Gulsen-Parman Y1, Oflazer-Serdaroglu P1, Deymeer F1.
Eur Neurol. 2017 Jul 28;78(3-4):137-142. doi: 10.1159/000479228.


Abstract
  • BACKGROUND:

    The difficult course of patients with myasthenia gravis (MG) with anti-muscle-specific tyrosine kinase antibodies (MuSK) has been emphasized. However, no clear information is available on patients who have a benign course.
  • METHODS:

    This study was aimed at comparing patients with favorable (minimal manifestations [MM] or better) and unfavorable outcomes to determine whether excellent response to corticosteroid (CS) treatment within 3 months (good response-3 months) has any predictive effect on the prognosis.
  • RESULTS:

    Forty-six percent of 46 patients had a favorable outcome at year 3 and 54% at final follow-up. The major finding of this study was its high predictive value with good response-3 months. Those with good response-3 months had significantly more favorable outcome as compared to those without at year 3. The positive predictive value of good response-3 months was high (89% at year 3 and 84% at final follow-up). The negative predictive value diminished from 85% at year 3 to 67% at final follow-up due to increasing number of patients improving in the long run. Overall, 33% of the patients had a benign course with good response-3 months and no major exacerbations until the end of follow-up.
  • CONCLUSIONS:

    Excellent response to CSs within 3 months appears to predict a favorable outcome in MuSK-MG.

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