La corrélation du rapport neutrophiles-lymphocytes avec la présence et l'activité de la myasthénie

Verrouillé
Avatar du membre

Auteur du sujet
Pboulanger Prés.
Administrateur
Administrateur
Messages : 10762
Enregistré le : 02 févr. 2010 18:41
14
Localisation  : La Chapelle en Serval F-60520
Genre :
Zodiaque :
Âge : 67
    Windows 10 Firefox

La corrélation du rapport neutrophiles-lymphocytes avec la présence et l'activité de la myasthénie

Message par Pboulanger Prés. »

:hi:

:arrow: Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29100295

[ligne][/ligne]

Traduction disponible directement en cliquant en bas à droite de ce message sur notre forum

Image

[ligne][/ligne]

The correlation of neutrophil-to-lymphocyte ratio with the presence and activity of myasthenia gravis.
Yang DH1, Qian MZ2, Wei MM3, Li J4, Yu MM5, Lu XM1, Yang H1, Lin H1, Li X4, Zhu JY3, Zhang X4.
Oncotarget. 2017 Jun 16;8(44):76099-76107. doi: 10.18632/oncotarget.18546. eCollection 2017 Sep 29.


Abstract

Though the pathogenesis of myasthenia gravis (MG) is not fully understood, the role of inflammation has been well appreciated in the development of MG.
We aimed to investigate the role of neutrophil-to-lymphocyte ratio (NLR) in MG patients and the relationship between the NLR and the activity of the disease. A total number of 172 MG patients and 207 healthy controls (HC) were enrolled in this study.

The MG patients were divided into tertiles according to NLR (low NLR < 1.58, n = 57; intermediate NLR 1.58-2.33, n = 57 and high NLR > 2.33, n = 58). The disease activity assessment was performed according to the standard criteria established by the Myasthenia Gravis Foundation of America. Patients with MG had significantly higher NLR when compared with the HC group (P < 0.0001).

The NLR levels were higher in the MG patients with severe disease activity than those with mild disease activity (P < 0.001), meanwhile, median NLR was statistically higher in MG patients with myasthenic crisis (MC) than those without MC (P < 0.001). Incidences of severe disease activity and MC were both higher in the high NLR group, compared to low and intermediate NLR groups (both P < 0.001).

Multivariate logistic regression analysis suggested that elevated NLR was an independent predictor of severe disease activity (odds ratio = 13.201, CI% = 1.418-122.938, P = 0.023). These results indicate that NLR may be a simple and useful potential marker in indicating disease activity in patients with MG.

Message d' un membre de l'équipe technique
Nous utilisons un service automatique de traduction fourni par YANDEX.
Soyez vigilant sur le risque de contre-sens inhérent à ce genre d'outils.

Lien direct Google Traduction https://translate.google.fr/translate?h ... 2F29100295
Amicalement,
Image
Verrouillé

Retourner vers « 2017 »