Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29266368
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Lien Google trad https://translate.google.fr/translate?h ... 2F29266368Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment.
Lv F1, Guan Y2, Ma D1, Xu X1, Song Y1, Li L1, Jiang Y1, Wang O1, Xia W1, Xing X1, Li M1.
Clin Endocrinol (Oxf). 2017 Dec 20. doi: 10.1111/cen.13537.
Glucocorticoids (GCs) are the first-line treatment for myasthenia gravis (MG) and act as long-term immunosuppressants. However, GCs can induce osteoporosis and bone fractures. In this study, we evaluate the effects of oral alendronate and alfacalcidol, or alfacalcidol alone on the bone of Chinese patients with MG who will initiate treatment with GCs.
- DESIGN AND METHODS:
A total of 75 patients were included in this 12-month prospective, open-label, single-center study. Patients with bone mineral density (BMD) T-score less than -1.0 at baseline were treated with 70 mg of alendronate per week. Patients with BMD T-score greater than -1.0 at baseline were included in the alfacalcidol alone group. Patients in two groups were treated with 0.25 μg of alfacalcidol every other day and 600 mg of calcium daily.
After 12 months of treatment, the mean BMD of lumbar spine, femoral neck, and total hip increased by 3.4% (p=0.002), 1.8% (p=0.21), and 2.6% (p=0.02), respectively in alendronate group. In alfacalcidol alone group, the mean BMD of lumbar spine, femoral neck, and total hip decreased by 6.1%, 3.2%, and 3.3%, respectively (all p<0.001 vs baseline).
We demonstrated for the first time that treatment with alendronate combined with alfacalcidol significantly increased BMD, decreased bone turnover biomarker levels, and reduced the occurrence of hypercalciuria in a large cohort of Chinese MG patients who initiated treatment with glucocorticoids. However, treatment with alfacalcidol alone failed to prevent bone loss in MG patients receiving glucocorticoid therapy.