Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29318185
[ligne][/ligne]
Traduction disponible directement en cliquant en bas à droite de ce message sur l'expression Traduire en
[ligne][/ligne]
Docetaxel/cisplatin Therapy in Myasthenia Gravis with Hypertension/diabetes.
Qi G1, Xue Y2, Li Y2, Yang H2, Zhang X2.
Open Med (Wars). 2017 Dec 2;12:403-408. doi: 10.1515/med-2017-0058. eCollection 2017.
Abstract
- Background:
Therapeutic options for thymoma-associated myasthenia gravis (MG) patients complicated with hypertension and/or diabetes post thymectomy are often conventional steroids. As the prevalence of diabetes and hypertension globally increases, other therapeutic options for these patients are of great importance.
- Material/methods:
9 patients with thymoma-associated MG complicated with hypertension and/or diabetes after thymectomy were administered 75 mg/m2 of docetaxel and 70 mg/m2 of cisplatin on day 1. The treatment could be repeated at 3-week intervals, ranging from 1 to 4 cycles according to the status of the patients. Therapeutic efficacy and side effects were evaluated.
- Results:
2 patients were complicated with type 2 diabetes, 6 with hypertension, and 1 with both diabetes and hypertension. After docetaxel/cisplain therapy, the MG symptoms were markedly improved in all patients (2, complete remission; 3, basic remission; 3, marked improvement; 1, improvement). Acetylcholine receptor (AchR) antibody levels were decreased in 8 patients. Minor adverse effects were observed in 2 patients, 1 with Grade II gastrointestinal reaction, and the other with pulmonary infection.
- Conclusion:
Docetaxel plus cisplatin might be an effective therapeutic option for thymoma-associated MG patients complicated with hypertension /diabetes post thymectomy without worsening thymoma and hypertension / diabetes.
Message d' un membre de l'équipe technique |
Pour les utilisateurs d'I-phone ci-dessous le lien vers Google Trad https://translate.google.fr/translate?h ... 2F29318185 |
Message d' un membre de l'équipe technique |
Nous utilisons des services automatiques de traduction fournis par Yandex ou Google. Soyez vigilant sur le risque de contre-sens inhérent à ce genre d'outils. |