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Fatigue is a relevant outcome in patients with Myasthenia Gravis.
Tran C1,2, Bril V2,3, Katzberg HD2,3, Barnett C2,3.
Muscle Nerve. 2018 Jan 17. doi: 10.1002/mus.26069.
Abstract
- INTRODUCTION:
Patients with myasthenia gravis often experience fatigue, but its effect on quality of life (QoL) is underestimated, and fatigue is rarely measured in clinical trials.
- METHODS:
257 myasthenic patients completed the Neuro-QoL-Fatigue and measures of disease severity and QoL. We studied the relationship between fatigue, clinical, and demographic variables. Finally, we studied the responsiveness of the Neuro-QoL-Fatigue in 95 patients receiving treatments for myasthenia, and estimated the minimal important difference (MID).
- RESULTS:
Fatigue was correlated with greater disease severity (r=0.52-0.69, P<0.0001) and worse QoL (r=0.65-0.75, P<0.0001). Patients in remission, minimal manifestation, and pure ocular symptoms reported minimal fatigue. Regression modeling showed that in addition to its relationship with disease severity, fatigue was worse in females, patients with generalized disease, or with anxiety/depression. Fatigue improved after immunomodulation (P<0.0001), and the MID was 5.3 points.
- DISCUSSION:
Fatigue in myasthenia correlates with disease severity, affects QoL, and can improve after treatment.
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