Etude clinique sur le pronostic des patients atteints de thymome avec myasthénie grave

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Pboulanger Prés.
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Etude clinique sur le pronostic des patients atteints de thymome avec myasthénie grave

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:arrow: Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29357966

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Clinical Study on the Prognosis of Patients with Thymoma with Myasthenia Gravis.
[Article in Chinese; Abstract available in Chinese from the publisher]
Yuan D1, Gu Z2, Liang G1, Fang W2, Li Y1; Chinese Alliance for Research of Thymoma Database.
Zhongguo Fei Ai Za Zhi. 2018 Jan 20;21(1):1-7. doi: 10.3779/j.issn.1009-3419.2018.01.01.


Abstract

  • BACKGROUND:

    Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors.
  • METHODS:

    A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way.
  • RESULTS:

    Thymic tumor tissue type credit has correlation with MG, difference was statistically significant (χ²=24.908, P<0.001). MG: incidence of B2 type (58/178, 32.58%) > B3 type (65/239, 27.20%) > B1 (27/132, 20.45%) > AB (43/267, 16.10%) > type A, 10.17% (6/59), Masaoka stage has no correlation with MG (χ²=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P<0.05), and whether the merger MG (χ²=0.113, P=0.736), postoperative adjuvant radiotherapy (χ²=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ²=14.417, P<0.001). Whether has nothing to do with the prognosis of the thymus resection (χ²=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ²=24.695, P<0.001).
  • CONCLUSIONS:

    Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.

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