Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29424940
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Thymus imaging in myasthenia gravis - the relevance in clinical practice
Klimiec E 1 , Quirke M 2 , Leite MI 2 , Hilton-Jones D 2 .
Nerve musculaire. 2018 9. février doi: 10.1002 / mus.26096.
The ability to distinguish between normal thymus, thymic hyperplasia and thymoma should aid clinical management and decision making in patients with myasthenia gravis. We aimed to determine the accuracy of routine imaging in predicting thymic pathology.
We retrospectively analyzed records of patients with myasthenia gravis from the Oxford Myasthenia Centre registry who underwent thymectomy. Each patient received one radiological diagnosis and one histological diagnosis.
We included 106 patients. Radiological and histological diagnoses agreed in 73 patients (68.9%). Sensitivity and specificity were calculated for each radiological diagnosis as follows: thymoma 90% and 95.5%; hyperplasia 17.6% and 98.6%; and normal 96.9% and 60.8% respectively.
Routine chest CT and MRI can effectively identify thymoma. However, they are not reliable tools to differentiate between thymic hyperplasia and normal thymus in MG patients.