Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/29699793
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Serum interleukin 15 levels in patients with seropositive myasthenia gravis do not correlate with disease severity.
Sobieszczuk E1, Kubiszewska J1, Lipowska M1, Szczudlik P1, Szyluk B1, Dutkiewicz M2, Kostera-Pruszczyk A3.
Neurol Neurochir Pol. 2018 Jan 6. pii: S0028-3843(17)30102-0. doi: 10.1016/j.pjnns.2017.12.011. [Epub ahead of print]
Abstract
- AIM:
To assess interleukin 15 (IL-15) serum levels in patients with seropositive myasthenia gravis (MG); searching for potential relationship between IL-15 levels and clinical features such as gender, age at onset, clinical presentation or treatment received.
- BACKGROUND:
IL-15 plays pivotal role in T-cell dependent autoimmunity. Increased IL-15 serum levels have been reported in several autoimmune diseases including MG patients from Japan.
PATIENTS AND METHODS:
Sera of 42 seropositive MG patients (66.7% women), mean age 50.6±23.7 years) have been tested by ELISA for IL-15 levels.
- RESULTS:
There were no statistically significant differences between IL-15 serum levels in MG patients in comparison with controls as well as between subgroups of MG patients (early vs. late onset and thymoma MG). Mean/median IL-15 serum levels were similar in MG patients treated with corticosteroids (CS) and CS naïve. Outliers (very high values) were seen only in untreated generalized MG patients.
- CONCLUSIONS:
Serum interleukin 15 levels in patients with seropositive myasthenia gravis do not correlate with disease severity.
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