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COVID ‐ 19 chez les patients atteints de myasthénie
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COVID‐19 in Patients with Myasthenia Gravis
Pria Anand MD Michaël C. C. Slama MD PhD Michelle Kaku MD Charlene Ong MD Anna M. Cervantes‐Arslanian MD Lan Zhou MD PhD William S. David MD PhD Amanda C. Guidon MD
First published: 11 May 2020
https://doi.org/10.1002/mus.26918
Abstract
Introduction
Coronavirus Disease 2019 (COVID‐19) has rapidly become a global pandemic, but little is known about potential impact on patients with myasthenia gravis (MG).
Methods
We studied the clinical course of COVID‐19 in 5 hospitalized patients with autoimmune MG (4 with acetylcholine receptor antibodies, one with muscle‐specific tyrosine kinase antibodies).
Results
Two patients required intubation for hypoxemic respiratory failure, while one required significant supplemental oxygen. One patient with previously stable MG had myasthenic exacerbation. One patient treated with tocilizumab for COVID‐19 was successfully extubated. Two patients were treated for MG with intravenous immunoglobulin without thromboembolic complications.
Discussion
Our findings suggest that the clinical course and outcomes in patients with MG and COVID‐19 are highly variable. Further large studies are needed to define best practices and determinants of outcomes in this unique population.
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https://onlinelibrary.wiley.com/doi/epdf/10.1002/mus.26918
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