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Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training
Martin Amadeus Rahbek MSc1,†, Erik Elgaard Mikkelsen MSc1,†,*, Kristian Overgaard PhD1, Lotte Vinge MD, PhD2, Henning Andersen MD, PhD2 andUlrik Dalgas PhD1
Version of Record online: 24 MAR 2017 DOI: 10.1002/mus.25552
ABSTRACT
- Introduction:
It has not been established whether progressive resistance training (PRT) and aerobic training (AT) are feasible and efficient in myasthenia gravis (MG).
- Methods:
Fifteen subjects with generalized MG (Myasthenia Gravis Foundation of America (MGFA) clinical classification II–IV) were randomly assigned to 20 training sessions during 8 weeks of either PRT or AT. Feasibility was evaluated based on adherence, drop-out rate, adverse events, and Quantitative Myasthenia Gravis (QMG) score.
- Results:
Twelve subjects (MGFA II, n = 11; MGFA III, n=1) completed the intervention with a mean adherence of 95 % ± 8. One dropout (PRT) could potentially be related to PRT. Both groups reported adverse events, including bulbar symptoms (n = 2) and increased fatigue (n = 3), but no change in QMG score was observed in either group. The PRT group showed increases in maximal strength and functional capacity.
- Conclusions:
Eight weeks of moderate to high intensity AT and PRT were feasible for most patients with mild MG. Maximal strength and functional capacity increased in the PRT group.
