Lu sur :https://www.ncbi.nlm.nih.gov/pubmed/30267806
[hr][/hr]
Traduction disponible directement en cliquant en bas à droite de ce message sur l'expression Traduire en
[hr][/hr]
West Nile virus induces a post-infectious pro-inflammatory state that explains transformation of stable ocular myasthenia gravis to myasthenic crises.
Hawkes MA1, Hocker SE1, Leis AA2.
J Neurol Sci. 2018 Sep 13;395:1-3. doi: 10.1016/j.jns.2018.09.015.
Abstract
West Nile virus (WNV) infection has been reported to promote myasthenia gravis (MG) and various other diseases that have a presumed autoimmune pathogenesis.
Molecular mimicry between WNV proteins and host proteins has been postulated as the major mechanism for WNV-triggered breaking of immunological self-tolerance.
We present a patient with stable ocular MG and positive anti-acetylcholine receptor antibodies who progressed to myasthenic crisis after WNV neuroinvasive disease.
In this case of stable autoimmune disease with proven auto-antibodies, transformation to generalized disease cannot be attributed to molecular mimicry, which requires that an immune response first be generated against an infectious agent.
Rather, the evidence supports the concept of a post-infectious pro-inflammatory state that may contribute to the amplification and promotion of autoimmune disease in some WNV survivors.
[hr][/hr]
Sur demande de nos donateurs, nous pouvons faire l'acquisition d'un tiré-à-part de l'article intégral
coût : $35,95 USD pris en charge par l’Association
[hr][/hr]
Message d' un membre de l'équipe technique |
Pour les utilisateurs d'I-phone ci-dessous le lien vers Google Trad https://translate.google.fr/translate?h ... 2F30267806 |
Message d' un membre de l'équipe technique |
Nous utilisons des services automatiques de traduction fournis par Yandex ou Google. Soyez vigilant sur le risque de contre-sens inhérent à ce genre d'outils. |