[Pubmed] Spontaneously resolving late-onset ocular myasthenia related to COVID-19. A case report

[RSS-Bot]

Acta Myol. 2023 Sep 30;42(2-3):89-91. doi: 10.36185/2532-1900-288. eCollection 2023.

ABSTRACT

Myasthenia gravis (MG) is the most common disease of the neuromuscular junction disorders with bimodal distribution of age, which is often under-estimated in the elderly. Some clinical cases show an association between MG and COVID-19, since molecular mimicry between SARS-CoV-2 and AChR proteins could be responsible for the onset of the disease. We report a 77-year-old woman who developed right eyelid ptosis five days after COVID-19 infection. Positive serum anti-acetylcholine receptor antibodies allowed the diagnosis of myasthenia gravis. It should be noted that there were no significant decremental changes on 3 Hz repetitive motor nerve stimulation study, even for the affected orbicularis oculi muscle. Clinical and pathophysiological data suggest that inflammation during COVID-19 could trigger an overproduction of autoantibodies previously present in the body at a subclinical level. This is the first case of COVID-19 infection complicated by myasthenia gravis, to the best of our knowledge, that resolves spontaneously.

PMID:38090545 | PMC:PMC10712660 | DOI:10.36185/2532-1900-288


Source: https://pubmed.ncbi.nlm.nih.gov/3809054 ... 2&v=2.18.0