[Pubmed] Treatment of Juvenile Myasthenia Gravis

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Brain Nerve. 2024 Jan;76(1):21-26. doi: 10.11477/mf.1416202553.

ABSTRACT

The pathogenesis of juvenile myasthenia gravis is similar to that of adult-onset cases, but does differ significantly in that it is predominantly ocular type, has a low antibody-positive rate, a low thymoma complication rate, and a high remission rate. The evidence for the adult treatment strategy of low-dose steroids and fast-acting treatment is insufficient in children, and the safety of immunosuppressive drugs has not been established. Steroid use in children in particular requires caution due to the risk of growth retardation, and while lower doses are desirable, the efficacy of lower doses has not been as fully investigated as in adults. Conversely, experience has shown that the use of adequate doses of steroids results in high remission rates, and there is currently no rationale for recommending lower doses.

PMID:38191135 | DOI:10.11477/mf.1416202553


Source: https://pubmed.ncbi.nlm.nih.gov/3819113 ... 9&v=2.18.0