[Pubmed] The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasth

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Front Immunol. 2025 Apr 15;16:1526317. doi: 10.3389/fimmu.2025.1526317. eCollection 2025.

ABSTRACT

The complement system is a key component of the innate immune system. In antiacetylcholine receptor (AChR) antibody-positive (Ab+) generalized myasthenia gravis (MG), complement activation has long been considered a principal driver of pathology. Understanding the role of complement in AChR-Ab+ generalized MG has gained increasing importance in recent years, as anticomplement drugs have been approved for clinical use or are undergoing phase II/III clinical trials. This review aims to discuss recent and previous findings on the role of complement in AChR-Ab+ MG pathology, including its interaction with pathogenic antibodies and mechanisms beyond the classical pathway activation.

PMID:40303417 | PMC:PMC12037622 | DOI:10.3389/fimmu.2025.1526317


Source: https://pubmed.ncbi.nlm.nih.gov/4030341 ... t9+e462414