[Pubmed] Acetylcholine receptor antibody-positive myasthenia gravis and Kennedy's disease overlap syndrome: a case repor

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Front Immunol. 2026 Jun 11;17:1872718. doi: 10.3389/fimmu.2026.1872718. eCollection 2026.

ABSTRACT

OBJECTIVE: To investigate the clinical characteristics and electromyographic findings of a patient with acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG) overlapping with Kennedy's disease (KD), aiming to improve clinicians' recognition of this rare overlap syndrome and explore potential comorbid mechanisms.

METHODS: The clinical presentation, laboratory results, and neurophysiological features of one case with AChR antibody-positive MG and KD were analyzed. A literature review of MG overlapping with KD was performed.

CONCLUSION: Neurophysiological findings and androgen receptor gene testing results were consistent with a diagnosis of KD. Therefore, the patient was definitively diagnosed with overlap syndrome of AChR antibody-positive MG and KD. A literature review identified only four previously reported cases of KD patients exhibiting myasthenic features; however, all were AChR antibody-negative.

PMID:42367789 | PMC:PMC13294539 | DOI:10.3389/fimmu.2026.1872718


Source: https://pubmed.ncbi.nlm.nih.gov/4236778 ... 2&v=2.20.0