Dommages aux cellules intestinales & activation immunitaire systémique chez des individus sensibles au blé ....

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Dommages aux cellules intestinales & activation immunitaire systémique chez des individus sensibles au blé ....

Message par Pboulanger » 27 juil. 2016 21:06

:hi:
Lu sur http://gut.bmj.com/content/early/2016/0 ... 016-311964 cette publication dont le titre peut être traduit par

"Dommages aux cellules intestinales et activation immunitaire systémique chez des individus ayant déclaré une sensibilité au blé en l'absence de la maladie cœliaque"

Traduction disponible directement en cliquant en bas à droite de ce message sur notre forum

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Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease
Melanie Uhde1, Mary Ajamian1, Giacomo Caio2, Roberto De Giorgio2, Alyssa Indart1, Peter H Green1,3, Elizabeth C Verna1, Umberto Volta2, Armin Alaedini1,3,4
1Department of Medicine, Columbia University Medical Center, New York, New York, USA
2Departments of Medical and Surgical Sciences and Digestive System, Centro di Ricerca Biomedica Applicata (C.R.B.A.), University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy
3Celiac Disease Center, Columbia University Medical Center, New York, New York, USA
4Institute of Human Nutrition, Columbia University Medical Center, New York, New York, USA


Correspondence to Dr Armin Alaedini, Department of Medicine, Columbia University Medical Center, 1130 Saint Nicholas Ave., Room 937; New York, NY 10032, USA; aa819{at}columbia.edu
Received 31 March 2016
Revised 9 June 2016
Accepted 20 June 2016




Abstract

  • Objective

    Wheat gluten and related proteins can trigger an autoimmune enteropathy, known as coeliac disease, in people with genetic susceptibility. However, some individuals experience a range of symptoms in response to wheat ingestion, without the characteristic serological or histological evidence of coeliac disease. The aetiology and mechanism of these symptoms are unknown, and no biomarkers have been identified. We aimed to determine if sensitivity to wheat in the absence of coeliac disease is associated with systemic immune activation that may be linked to an enteropathy.
  • Design Study

    participants included individuals who reported symptoms in response to wheat intake and in whom coeliac disease and wheat allergy were ruled out, patients with coeliac disease and healthy controls. Sera were analysed for markers of intestinal cell damage and systemic immune response to microbial components.
  • Results

    Individuals with wheat sensitivity had significantly increased serum levels of soluble CD14 and lipopolysaccharide (LPS)-binding protein, as well as antibody reactivity to bacterial LPS and flagellin. Circulating levels of fatty acid-binding protein 2 (FABP2), a marker of intestinal epithelial cell damage, were significantly elevated in the affected individuals and correlated with the immune responses to microbial products. There was a significant change towards normalisation of the levels of FABP2 and immune activation markers in a subgroup of individuals with wheat sensitivity who observed a diet excluding wheat and related cereals.
  • Conclusions

    These findings reveal a state of systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of coeliac disease.
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