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Fatigue in myasthenia gravis: risk factors and impact on quality of life
Authors Sarah Hoffmann 1,2 | Johanna Ramm 1 | Ulrike Grittner 3,4 | Siegfried Kohler 1,2 |
Jana Siedler 1 | Andreas Meisel 1,2
First published: 2 August 2016Full publication history
Emerging evidence suggests that fatigue in myasthenia gravis (MG) is a relevant problem that negatively impacts activities of daily living (ADL). The relation-ship between fatigue and quality of life (QoL) has never been systematically explored in MG patients. The study aimed to assess the revalence of fatigue and its relation to ADL and QoL as well as to identify factors associated with fatigue in MG.
- Material and methods:
This was a cross- sectional observational study in patients with confirmed diagnosis of MG independent of disease severity. Prevalence of fatigue was
assessed using the Chalder Fatigue Scale (CFQ). Impact of fatigue on ADL and QoL was assessed by the MG activities of daily living profile (MG- ADL) and the MG- specific quality- of- life instrument (MG- QoL), respectively. Association of fatigue with sociode-mographics, clinical characteristics of MG, and comorbidities including mood and anxi-ety disorders as well as sleep disorders was investigated using multivariable logistic regression analyses.
Overall, 200 MG patients were included. The observed rate of fatigue was 56.1%, of those 70.4% fulfilled the criteria of chronic fatigue (CF) with a duration of ≥6 months. Relevant fatigue was strongly associated to ADL and QoL. Factors associated with relevant fatigue were disease severity and depressive state. Furthermore, positive muscle- specific tyrosine kinase (MuSK) antibody status showed a strong association with relevant fatigue.
MG patients have a high prevalence of fatigue which negatively impacts ADL and QoL. MG- specific clinical characteristics are related to fatigue and might help to identify MG patients at risk for fatigue.