Fatigue cognitive chez les patients myasthéniques

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Pboulanger
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Fatigue cognitive chez les patients myasthéniques

Message par Pboulanger » 09 janv. 2017 11:03

:hi:

Lu sur https://www.ncbi.nlm.nih.gov/pubmed/28033668
Traduction disponible directement en cliquant en bas à droite de ce message sur notre forum

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Cognitive fatigue in patients with myasthenia gravis.
Jordan B1, Schweden TL2, Mehl T1, Menge U2, Zierz S1.
PMID: 28033668 DOI: 10.1002/mus.25540

Abstract
  • INTRODUCTION:
    Cognitive fatigue has frequently been reported in myasthenia gravis (MG). However, objective assessment of cognitive fatigability has never been evaluated.
  • METHODS:
    Thirty-three MG patients with stable generalized disease and 17 healthy controls underwent a test battery including repeated testing of attention and concentration (d2-R) and PASAT (Paced Auditory Serial Addition Test). Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Additionally, fatigue questionnaires were used.
  • RESULTS:
    MG patients showed a negative LT in second d2-R testing, indicating cognitive fatigability. This finding significantly differed from stable cognitive performance in controls (P<0.05). Results of PASAT testing did not differ between groups. Self-assessed fatigue was significantly higher in MG patients compared to controls (P<0.001), but did not correlate with LT.
  • DISCUSSION:
    LT quantifies cognitive fatigability as an objective measurement of performance decline in MG patients. Self-assessed cognitive fatigue is not correlated with objective findings. This article is protected by copyright. All rights reserved.
Amicalement,
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