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Cognitive fatigue in patients with myasthenia gravis.
Jordan B1, Schweden TL2, Mehl T1, Menge U2, Zierz S1.
PMID: 28033668 DOI: 10.1002/mus.25540
Cognitive fatigue has frequently been reported in myasthenia gravis (MG). However, objective assessment of cognitive fatigability has never been evaluated.
Thirty-three MG patients with stable generalized disease and 17 healthy controls underwent a test battery including repeated testing of attention and concentration (d2-R) and PASAT (Paced Auditory Serial Addition Test). Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Additionally, fatigue questionnaires were used.
MG patients showed a negative LT in second d2-R testing, indicating cognitive fatigability. This finding significantly differed from stable cognitive performance in controls (P<0.05). Results of PASAT testing did not differ between groups. Self-assessed fatigue was significantly higher in MG patients compared to controls (P<0.001), but did not correlate with LT.
LT quantifies cognitive fatigability as an objective measurement of performance decline in MG patients. Self-assessed cognitive fatigue is not correlated with objective findings. This article is protected by copyright. All rights reserved.