[pubmed] Modulation of immune responses by bile acid receptor agonists in myasthenia gravis
Posté : 26 sept. 2020 12:00
J Neuroimmunol. 2020 Sep 18;349:577397. doi: 10.1016/j.jneuroim.2020.577397. Online ahead of print.
ABSTRACT
Bile acids bind to multiple receptors, including Takeda G protein-coupled receptor 5 (TGR5) and farnesoid-X-receptors alpha (FXRα). We compared the response of PBMCs to the activation of these receptors in healthy controls and myasthenic patients. We found that TGR5 is a more potent negative regulator of T cell cytokine response than FXRα in both groups. In contrast, TGR5 and FXRα agonists elicit distinct B cell responses in myasthenia compared to controls, specifically on the frequency of IL-6+ B cells and regulatory B cells, as well as IL-10 secretion from PBMCs. We propose that TGR5 is a potential therapeutic target in myasthenia.
PMID:32979707 | DOI:10.1016/j.jneuroim.2020.577397
Source: https://pubmed.ncbi.nlm.nih.gov/3297970 ... 9&v=2.11.5