[pubmed] Myasthenia Gravis and Large Granular Lymphocytic Leukemia: a rare association
Posté : 23 oct. 2020 12:00
Leuk Res Rep. 2020 Oct 6;14:100226. doi: 10.1016/j.lrr.2020.100226. eCollection 2020.
ABSTRACT
Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorder sometimes observed in hematologic malignancies as a paraneoplastic syndrome. T-cell Large Granular Lymphocytic Leukemia (T-LGLL) is a rare lymphoproliferative clonal frequently associated with autoimmune disorders. Here we report two patients with T-LGLL who developed MG. In both patients the MG was bulbar without generalized weakness and did not involve the thymus. The treatment of T-LGLL led to the resolution of MG symptoms and decrease in acetylcholine receptor antibody titers in both patients suggesting a causative association.
PMID:33094093 | PMC:PMC7568180 | DOI:10.1016/j.lrr.2020.100226
Source: https://pubmed.ncbi.nlm.nih.gov/3309409 ... 4&v=2.12.6