[Pubmed] Thymectomy for myasthenia gravis: A pathological analysis

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[Pubmed] Thymectomy for myasthenia gravis: A pathological analysis

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Indian J Pathol Microbiol. 2022 Jan-Mar;65(1):129-132. doi: 10.4103/IJPM.IJPM_935_20.

ABSTRACT

BACKGROUND: Myasthenia gravis (MG) is a prototypic T-cell-dependent antibody-mediated autoimmune disease that leads to ocular or generalized muscular weakness. The disease is most commonly caused by antibodies to the acetylcholine receptors, often with underlying thymic pathology.

AIMS: This study is aimed at analyzing the pathological spectrum of the excised thymuses in patients with myasthenia.

MATERIALS AND METHODS: This was a retrospective 10-year study of 68 thymectomy specimens performed as a part of the treatment of patients with MG.

STATISTICAL ANALYSIS: Nil.

RESULTS: There were 47 males and 21 females (male to female ratio of 2.2:1) with a mean age of 41 years. Only three patients presented with ocular myasthenia. The thymus was normal in 9 patients (13.2%) and atrophic in 17 patients (25%). Follicular hyperplasia and thymomas were seen in 6 and 36 patients, respectively.

CONCLUSION: The thymectomies performed in patients of MG had a fairly variable spectrum on histology; the thymic tumors were predominantly of the cortical phenotype.

PMID:35074977 | DOI:10.4103/IJPM.IJPM_935_20


Source: https://pubmed.ncbi.nlm.nih.gov/3507497 ... 9&v=2.17.5
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