[Pubmed] The effect of immunosuppression or thymectomy on the response to tetanus revaccination in myasthenia gravis
Posté : 29 juil. 2022 12:00
J Neuroimmunol. 2022 Sep 15;370:577930. doi: 10.1016/j.jneuroim.2022.577930. Epub 2022 Jul 12.
ABSTRACT
OBJECTIVE: To determine the effect of tetanus toxoid (TT) revaccination on circulating B-, T- and NK-cell compartments in myasthenia gravis (MG) patients.
METHODS: Lymphocyte (sub)populations and differentiation stages were assessed by flow cytometry in 50 TT revaccinated MG patients. TT-specific proliferative responses were explored in PBMC cultures.
RESULTS: In patients treated with azathioprine B- and NK cell numbers were strongly decreased. Lymphocyte (sub)populations remained unaffected upon TT revaccination. t All patients showed a significant TT-induced proliferative response.
CONCLUSION: TT revaccination is effective in MG patients with stable disease irrespective of their thymectomy status and medication and does not alter the composition of the lymphocyte compartment.
PMID:35905614 | DOI:10.1016/j.jneuroim.2022.577930
Source: https://pubmed.ncbi.nlm.nih.gov/3590561 ... 4&v=2.17.7