[Pubmed] Myasthenia gravis as an unusual non-hematological autoimmune manifestation of a relapsed chronic lymphocytic le
Posté : 03 févr. 2023 12:00
Eur Rev Med Pharmacol Sci. 2023 Jan;27(2):649-652. doi: 10.26355/eurrev_202301_31066.
ABSTRACT
BACKGROUND: Autoimmune phenomena are well known to complicate chronic lymphocytic leukemia (CLL) and occur in 10% to 25% of the cases. Although less common, non-hematological autoimmune manifestations have been reported. Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, characterized by fatigable weakness of the extraocular, bulbar, and limb musculature. The co-existence of MG and CLL is exceedingly rare and there are very few cases reported in literature.
CASE PRESENTATION: We present a case of a 63-year-old female patient with a severe form of MG which is likely related to a relapse of CLL. Treatment with combined targeted and immunotherapy was initiated with acceptable tolerability.
CONCLUSIONS: Targeted agents and monoclonal antibodies exert complex activities on the patient's immune system. It will be of interest to assess their role in managing autoimmune complications, accompanying CLL.
PMID:36734734 | DOI:10.26355/eurrev_202301_31066
Source: https://pubmed.ncbi.nlm.nih.gov/3673473 ... t6+86293ac