[Pubmed] A case of thymoma-associated myasthenia gravis accompanied with myositis showing the clusters of histiocyte alo

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Clin Neurol Neurosurg. 2023 Apr 11;229:107715. doi: 10.1016/j.clineuro.2023.107715. Online ahead of print.

ABSTRACT

Patients with myasthenia gravis (MG) often have other autoimmune disorders. However, the coexistence of MG and myositis is rare. Here, we report a case of a 77-year-old woman who developed mild fatigable muscle weakness and diplopia in 3 months. Serum creatine kinase was elevated to 1385 IU/L. Antibodies to acetylcholine receptor (AChR), titin and voltage-gated potassium channel 1.4 (Kv 1.4) were all positive while all tested myositis-specific autoantibodies were negative. Standard needle electromyography showed fibrillation potential and early recruitment of motor units. The repetitive nerve stimulations were consistent with a disorder of the neuromuscular junction. Muscle biopsy showed that the clusters of histiocyte were present along the fascicles in perimysium and some of them invaded into endomysium.

PMID:37068437 | DOI:10.1016/j.clineuro.2023.107715


Source: https://pubmed.ncbi.nlm.nih.gov/3706843 ... t6+86293ac