[Pubmed] A case of anti-acetylcholine receptor antibody-positive ocular myasthenia gravis with anti-titin antibody and a

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Rinsho Shinkeigaku. 2023 Nov 22. doi: 10.5692/clinicalneurol.cn-001908. Online ahead of print.

ABSTRACT

An 84-year-old man was diagnosed with anti-acetylcholine receptor (AChR) antibody-positive ocular myasthenia gravis (OMG) at the age of 77 and received treatment. The patient was referred to our department with swelling and pain in his right upper arm, which had spread to other limbs. His serum anti-AChR antibody and creatine kinase levels were elevated, and MRI of the limbs displayed signal changes suggesting inflammation in the several muscles. Despite showing no sign of thymoma, he was positive for serum anti-titin and anti-Kv1.4 antibodies. We performed a muscle biopsy, which led to a diagnosis of inflammatory myopathy (IM). IM associated with OMG is relatively mild. Age-related immune dysregulation may cause both OMG and IM. Evaluation of disease activity with serum anti-AChR antibody levels, and assessment of prognosis with examining anti-striational antibodies are necessary for appropriate management of IM associated with MG.

PMID:37989286 | DOI:10.5692/clinicalneurol.cn-001908


Source: https://pubmed.ncbi.nlm.nih.gov/3798928 ... t6+86293ac