[Pubmed] MuSK Myasthenia Gravis-Potential Pathomechanisms and Treatment Directed against Specific Targets

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Cells. 2024 Mar 21;13(6):556. doi: 10.3390/cells13060556.

ABSTRACT

Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies target structures within the neuromuscular junction, affecting neuromuscular transmission. Muscle-specific tyrosine kinase receptor-associated MG (MuSK-MG) is a rare, often more severe, subtype of the disease with different pathogenesis and specific clinical features. It is characterized by a more severe clinical course, more frequent complications, and often inadequate response to treatment. Here, we review the current state of knowledge about potential pathomechanisms of the MuSK-MG and their therapeutic implications as well as ongoing research in this field, with reference to key points of immune-mediated processes involved in the background of myasthenia gravis.

PMID:38534400 | DOI:10.3390/cells13060556


Source: https://pubmed.ncbi.nlm.nih.gov/3853440 ... t9+e462414