[Pubmed] Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma asso
Posté : 11 mai 2024 12:00
J Neuroinflammation. 2024 May 11;21(1):126. doi: 10.1186/s12974-024-03095-7.
ABSTRACT
Myasthenia gravis (MG) is an immune-mediated disease frequently associated with thymic changes. Increased T helper 17 (Th17) cell activity and dysfunctional regulatory T (Treg) cells have been demonstrated in subgroups of MG. On the other hand, hypoxia-inducible factor 1 (HIF-1) has been shown to regulate the Th17/Treg balance by inducing Th17 differentiation while attenuating Treg development. To identify the underlying mechanisms of different thymic pathologies in MG development, we evaluated thymic samples from thymoma-associated myasthenia gravis (TAMG), MG with hyperplasia (TFH-MG) and thymoma without MG (TOMA) patients. Differential gene expression analysis revealed that TAMG and TFH-MG cells are associated with different functional pathways. A higher RORC/FOXP3 ratio provided evidence for Th17/Treg imbalance in TAMG potentially related to increased HIF1A. The hypoxic microenvironment in thymoma may be a driver of TAMG by increasing HIF1A. These findings may lead to new therapeutic approaches targeting HIF1A in the development of TAMG.
PMID:38734662 | DOI:10.1186/s12974-024-03095-7
Source: https://pubmed.ncbi.nlm.nih.gov/3873466 ... t9+e462414