[Pubmed] Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic predictio
Posté : 13 nov. 2024 12:00
Nat Commun. 2024 Nov 13;15(1):9839. doi: 10.1038/s41467-024-53595-6.
ABSTRACT
Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a replication study in 3989 cases and 226,643 controls provided by 23andMe Inc. We identified 12 independent genome-wide significant hits (P < 5e-8) across 11 loci. Subgroup analyses revealed two of these were associated with early-onset (at age
Source: https://pubmed.ncbi.nlm.nih.gov/3953760 ... t9+e462414