[Pubmed] Global Research Landscape in T Cells and Myasthenia Gravis: Trends, Collaborations, and Future Directions

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Mol Neurobiol. 2026 Feb 5;63(1):419. doi: 10.1007/s12035-025-05523-y.

ABSTRACT

Myasthenia gravis (MG) has emerged as a significant global public health concern. A growing number of studies have focused on T cells in the pathophysiology of MG given that they regulate the immune response and affect autoantibody formation, which leads to the progression of the disease. Currently, there are no comprehensive studies on T cells and MG. Therefore, it is imperative to address this key area through bibliometric analysis and exploration of molecular mechanisms, which will provide essential guidance for investigating fundamental pathological processes and enhancing clinical management. Firstly, we investigated the Web of Science™ Core Collection and the PubMed database for relevant literature, assessing temporal and spatial distribution, the leading research center, key investigators, influential journals, topic hotspot evolution, references, and keywords. CiteSpace and VOSviewer were used for visualizing. Over the past decade, research on T cells and MG has gained curiosity and enthusiasm. Then, we reviewed key research areas which are the roles of T cell subsets, B cell subsets, cytokines, ICI-MG, and new immunotherapy, etc. Notably, we also highlighted emerging T cell-related research fields, such as CAR-T cell therapy and extracellular vesicle-based drug delivery. These cutting-edge directions hold particular promise for promoting interdisciplinary studies and personalized therapies, ultimately bridging the gap between foundational research and clinical implementation.

PMID:41642475 | DOI:10.1007/s12035-025-05523-y


Source: https://pubmed.ncbi.nlm.nih.gov/4164247 ... 22+67771e2