[Pubmed] Management of Pregnancy Due to Concern for Preeclampsia in a Woman with Myasthenia Gravis, Chronic Hypertension
Posté : 13 avr. 2026 12:00
Harefuah. 2026 Apr;165(4):221-224.
ABSTRACT
Myasthenia gravis (MG) is an autoimmune disease impairing neuromuscular transmission due to antibodies against acetylcholine receptors. Preeclampsia is a pregnancy-specific hypertensive disorder that can lead to seizures and cerebral complications, typically prevented with IV magnesium sulfate. In MG patients, magnesium is contraindicated as it inhibits acetylcholine release, worsening muscle weakness and risking respiratory failure. We present a pregnant MG patient with additional preeclampsia risk factors: nulliparity, age, epilepsy, gestational diabetes and chronic hypertension. Due to limited literature, a tailored protocol was created including instructions to: avoid magnesium; use levetiracetam or diazepam for seizures; control blood pressure with hydralazine; add labetalol if needed; Cesarean only for obstetric reasons and to ensure team awareness and minimize stress. This case emphasizes the need for individualized care in high-risk pregnancies with MG.
PMID:41972441
Source: https://pubmed.ncbi.nlm.nih.gov/4197244 ... t6+133c1fe