[Pubmed] Research Progress of CAR-T Cell Therapy in Autoimmune Diseases --Review

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Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2026 Apr;34(2):612-616. doi: 10.19746/j.cnki.issn1009-2137.2026.02.047.

ABSTRACT

Chimeric antigen receptor T (CAR-T) cell therapy has achieved significant success in the field of hematologic oncology. Considering the similarities in the origin and circulatory distribution between hematopoietic tumor cells and autoantigen-specific immune cells, research has commenced to apply CAR-T cell therapy to autoimmune diseases, yielding encouraging preliminary findings. This article reviews the mechanisms of action and clinical research data of CAR-T cells in diseases such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, myasthenia gravis, and rheumatoid arthritis in recent years, with the aim of providing a broader perspective for the future application of CAR-T cells in the field of autoimmune diseases.

PMID:42227466 | DOI:10.19746/j.cnki.issn1009-2137.2026.02.047


Source: https://pubmed.ncbi.nlm.nih.gov/4222746 ... 2&v=2.20.0