[Pubmed] Progressive Bulbar Weakness in an Older Male With Suspected Double-Seronegative Myasthenia Gravis Culminating i
Posté : 29 juin 2026 12:00
Cureus. 2026 May 27;18(5):e109753. doi: 10.7759/cureus.109753. eCollection 2026 May.
ABSTRACT
Myasthenia gravis is a rare autoimmune disorder affecting the neuromuscular junction, causing muscle weakness that worsens with use and improves with rest. While it is typically diagnosed through antibody tests or electrophysiological testing, a smaller subset of the population is seronegative or may have inconclusive electrophysiological results. In emergent presentations, seronegative myasthenia gravis is a challenge to diagnose clinically, making it imperative to identify it early to ensure proper management and treatment. Here, we present the case of an older male with a complex medical history and suspected seronegative myasthenia gravis who through the course of his admission experienced myasthenic crisis necessitating treatment with both intravenous immunoglobulin and plasmapheresis.
PMID:42367493 | PMC:PMC13307525 | DOI:10.7759/cureus.109753
Source: https://pubmed.ncbi.nlm.nih.gov/4236749 ... 2&v=2.20.0