Syndrome de chevauchement MG Lambert-Eaton

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Syndrome de chevauchement MG Lambert-Eaton

Message par Pboulanger » 27 nov. 2015 09:11

:hi:

Lu sur Willey online http://onlinelibrary.wiley.com/doi/10.1 ... avedsearch
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Myasthenia gravis Lambert-Eaton overlap syndrome
Shin J. Oh MD*

Article first published online: 26 NOV 2015
DOI: 10.1002/mus.24921


ABSTRACT

Introduction:
To assess whether a myasthenia gravis (MG) Lambert-Eaton overlap syndrome (MLOS) exists.

Methods:
Case reports that met the universally accepted diagnostic criteria for MG and Lambert-Eaton myasthenic syndrome (LEMS) were sought through a PubMed search. Fifty-five possible cases of MLOS were identified.

Results:
Thirty-nine cases met the diagnostic criteria for MG and LEMS. Analysis of clinical features showed that these patients have common MG and LEMS symptoms: oculo-bulbar paresis and good response to anti-cholinesterase for MG and limb weakness and decreased or absent reflexes for LEMS. All had the classical LEMS pattern in the repetitive nerve stimulation test: low compound muscle action potential amplitude and incremental response > 60% with brief exercise or at high rate of stimulation. Eight patients had combined positive acetylcholine receptor antibody (AChR-ab) or muscle-specific kinase-ab and voltage-gated calcium channel- ab tests.

Conclusions:
A myasthenia gravis Lambert-Eaton overlap syndrome (MLOS) does exist.

Muscle Nerve, 2015
Amicalement,
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