[pubmed] Anti-MuSK positive myasthenia gravis with anti-Lrp4 and anti-titin antibodies

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Intern Med. 2020 Aug 22. doi: 10.2169/internalmedicine.4957-20. Online ahead of print.

ABSTRACT

In addition to muscle nicotinic acetylcholine receptor (AChR) and muscle-specific kinase (MuSK), low-density lipoprotein receptor (Lrp4) has recently been discovered to be a novel target antigen among patients with seronegative myasthenia gravis (MG). We herein report the findings of a 62-year-old patient who showed positivity for anti-MuSK, anti-Lrp4, and anti-titin antibodies. The patient developed MG crisis following a 10-year history of intermittent double vision with ptosis, and a 7-year history of dropped head. Our detailed clinical, laboratory, and therapeutic descriptions highlight its unique characteristics of anti-MuSK-antibody positive MG accompanied by anti-Lrp4 and anti-titin antibodies.

PMID:32830177 | DOI:10.2169/internalmedicine.4957-20


Source: https://pubmed.ncbi.nlm.nih.gov/3283017 ... 1&v=2.11.5