[Pubmed] Myasthenic crisis in thymoma-associated myasthenia gravis: a multicenter retrospective cohort study

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Neuromuscul Disord. 2023 Sep 22:S0960-8966(23)00731-9. doi: 10.1016/j.nmd.2023.09.005. Online ahead of print.

ABSTRACT

Thymoma-associated myasthenia gravis (TMG) had more severe symptoms and worse prognoses in comparison to non-thymoma-associated MG. Thymoma recurrence was frequently associated with transient worsening of MG and even acute respiratory failure, namely myasthenic crisis (MC). However, little is known about the clinical features and outcomes of MC in thymoma-associated MG patients. We performed a retrospective cohort study in MG patients recruited from 9 independent tertiary neuromuscular centers in China from Jan 2015, through Oct 2022. Overall, 156 MC from 149 MG patients with positive anti-acetylcholine receptor (AChR) antibodies were finally analyzed. Next, these patients were divided into two subgroups: the TMG group (n = 60 MCs, 58 patients) and the non-thymoma-associated MG group (n = 96 MCs, 91 patients). Compared with non-thymoma-associated MG, TMG patients had a significantly shorter disease duration from symptom onset to the crisis (17.95±40.9 vs 51.31±60.61 months, P

Source: https://pubmed.ncbi.nlm.nih.gov/3778362 ... t6+86293ac