[SMLE] A 50 year old man with progressive weakness in lower limbs

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Laeknabladid. 2023 Nov;109(11):508-512. doi: 10.17992/lbl.2023.11.768.

ABSTRACT

Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neurological disorder caused by autoimmune antibodies attacking the presynaptic neuromuscular junction, in some cases caused by underlying cancer. The main clinical finding is fluctuating weakness of the extremities and a triad of symtoms can help physicians suspect the disease. A key to the diagnosis are the electrophysiological abnormalities seen in this group of diseases. Treatment with symtomatic and/or immunosuppressive therapy is important as well as a workup for possible malignancy. This article identifies the clinical features, diagnosis and treatment of this uncommon disease.

PMID:37909447 | DOI:10.17992/lbl.2023.11.768


Source: https://pubmed.ncbi.nlm.nih.gov/3790944 ... t6+86293ac