[Pubmed] Elevated serum levels of C-terminal agrin fragment in acetylcholine receptor antibody-positive myasthenia gravi

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J Neuroimmunol. 2024 Sep 10;396:578455. doi: 10.1016/j.jneuroim.2024.578455. Online ahead of print.

ABSTRACT

Agrin is essential for neuromuscular junction (NMJ) formation and maintenance. The C-terminal agrin fragment (CAF), generated by neurotrypsin-mediated cleavage of agrin, has been gaining attention as a potential biomarker for sarcopenia. We investigated serum CAF levels in myasthenia gravis (MG), a NMJ disorder. Compared to healthy controls, serum CAF levels were significantly elevated in acetylcholine receptor antibody-positive MG (AChR-MG) patients, but not in muscle-specific kinase antibody-positive MG patients. In AChR-MG, baseline and post-treatment CAF levels inversely correlated with post-treatment MG activities of daily living scores, suggesting that elevated CAF levels may reflect protective mechanisms against AChR-MG pathogenesis, such as improved NMJ regeneration.

PMID:39276618 | DOI:10.1016/j.jneuroim.2024.578455


Source: https://pubmed.ncbi.nlm.nih.gov/3927661 ... t9+e462414