[Pubmed] Good's Syndrome Revealed by Recurrent Sigmoid Diverticulitis

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Eur J Case Rep Intern Med. 2025 Jun 5;12(7):005480. doi: 10.12890/2025_005480. eCollection 2025.

ABSTRACT

Thymus is a primary lymphoid organ whose main function is the education of the T lymphocytes. Thymoma is uncommon neoplasia derived from epithelial cells of the thymus. Patients with thymoma frequently present with autoimmune disorders, mostly myasthenia gravis. Good's syndrome (GS) is an acquired adult-onset combined immunodeficiency typically characterised by the triad of thymoma, hypogammaglobulinaemia and increased susceptibility to recurrent infections. Immunoglobulin replacement is the main therapeutic strategy. Our knowledge of thymoma-associated immunodeficiency is predominantly derived from case reports or small series. We report the case of a patient with recurrent sigmoid diverticulitis that appeared after a thymectomy, who was subsequently found to have severe hypogammaglobulinaemia.

LEARNING POINTS: Good's syndrome is a rare, acquired, adult-onset immunodeficiency.Good's syndrome remains an enigmatic disease.Immunoglobulin replacement is the main therapeutic strategy.

PMID:40636243 | PMC:PMC12236679 | DOI:10.12890/2025_005480


Source: https://pubmed.ncbi.nlm.nih.gov/4063624 ... t9+e462414