[Pubmed] Predictors of Quality of Life in Myasthenia Gravis Patients from Southwestern China: Validation of Clinical and

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Neuroepidemiology. 2025 Sep 2:1-20. doi: 10.1159/000548274. Online ahead of print.

ABSTRACT

INTRODUCTION: Myasthenia gravis (MG) presents a substantial clinical burden, characterized by increased incidence of myasthenic crises, heterogeneity in treatment response, significant functional impairment, and gradually increasing mortality rates with marked geographical heterogeneity across China. While improving quality of life (QOL) is the focus of MG management, multifactorial determinants of QOL impairment remain unclear, especially in socioeconomically underrepresented regions, particularly Southwestern China. This study aimed to explore myasthenia-specific risk factors for QOL and develop a parsimonious prediction model.

METHODS: This study performed univariate and multivariate regression analyses on 310 myasthenia gravis (MG) patients diagnosed at the First Affiliated Hospital of Chongqing Medical University between January 2022 and February 2025 from Southwestern China. The QOL of patients was evaluated with the 15-item Myasthenia Gravis Quality of Life (MG-QOL15). Disease severity was evaluated with current Myasthenia Gravis Foundation of America (MGFA) classification, MG-related activities of daily living (MG-ADL) score and quantitative myasthenia gravis (QMG) score. Relevant clinical and demographic data were included in the analysis.

RESULTS: In the analysis of basic characteristics, higher ADL (P

Source: https://pubmed.ncbi.nlm.nih.gov/4089271 ... t9+e462414