[Pubmed] Myasthenic Crisis in a Patient Initially Treated for Transient Ischaemic Attack and Infection: A Case Report

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Cureus. 2025 Sep 29;17(9):e93511. doi: 10.7759/cureus.93511. eCollection 2025 Sep.

ABSTRACT

Myasthenia gravis (MG) is the most common disorder of the neuromuscular junction and may present with fluctuating ocular, bulbar, or limb weakness. Myasthenic crisis represents a life-threatening complication characterised by respiratory failure requiring ventilatory support. We report the case of a 46-year-old South Asian man who initially presented with fluctuating bilateral ptosis, intermittent diplopia, and fatigue, and was managed as a transient ischaemic attack and respiratory tract infection. He subsequently deteriorated with hypoxia, extensive secretion burden, and pneumonia, necessitating intubation and intensive care admission. Despite broad-spectrum antibiotics and supportive care, ventilatory requirements persisted. Following neurological review and a more detailed history, together with multidisciplinary discussion, a myasthenic crisis was suspected, and treatment with intravenous immunoglobulin and corticosteroids was initiated. Acetylcholine receptor antibodies later returned positive, and electromyography demonstrated a decremental response, confirming the diagnosis. The patient improved gradually, was extubated on Day 14, and discharged with immunosuppressive therapy and neurology follow-up. This case underscores the importance of thorough neurological examination and careful history-taking to support early diagnosis, alongside timely multidisciplinary team input to guide management.

PMID:41170262 | PMC:PMC12571490 | DOI:10.7759/cureus.93511


Source: https://pubmed.ncbi.nlm.nih.gov/4117026 ... 22+67771e2